EDITORIAL
| A Synthesis Is Not the Same as a Process Trevor Laird 783-783 |
| Full: PDF (42 K) |
HIGHLIGHTS FROM THE LITERATURE
| Some Items of Interest to Process R&D Chemists and Engineers Mark McLaughlin, Silvina García Rubio, Matthew Pfeiffer, Ulf Tilstam, Joseph Swaroop Mathen, Octavio Augusto Ceva Antunes, Trevor Laird*, and Andrei A. Zlota 784-796 |
| Full: PDF (298 K) |
REGULATORY HIGHLIGHTS
| Regulatory Highlights for January to August 2007 Derek Robinson 797-801 |
| Full: PDF (74 K) |
HIGHLIGHTS FROM THE PATENTS
| A Review of U.S. Patents in the Field of Organic Process Development Published During April and May 2007 Keith Turner 802-812 |
| Full: PDF (332 K) |
FULL PAPERS
| Convergent Approach for Commercial Synthesis of Gefitinib and Erlotinib Venkateshappa Chandregowda, Gudapati Venkateswara Rao, and Goukanapalli Chandrasekara Reddy 813-816  |
| Full: PDF (101 K) |
| Purification of Difluoromethylornithine by Global Process Optimization: Coupling of Chemistry and Chromatography with Enantioselective Crystallization Scott R. Perrin, Wilhelm Hauck, Elias Ndzie, Jean Blehaut, Olivier Ludemann-Hombouger, Roger-Marc Nicoud, and William H. Pirkle 817-824  |
| Full: PDF (282 K) |
| A Concise Synthesis of a Novel Insulin-Like Growth Factor I Receptor (IGF-IR) Inhibitor Joel Slade, Joginder Bajwa, Hui Liu, David Parker, James Vivelo, Guang-Pei Chen, John Calienni, Edwin Villhauer, Kapa Prasad, Oljan Repič, and Thomas J. Blacklock 825-835  |
| Full: PDF (264 K) |
| Process Intensification for Substrate-Coupled Whole Cell Ketone Reduction by In Situ Acetone Removal Kirsten Schroer, Eva Tacha, and Stephan Lütz 836-841  |
| Full: PDF (143 K) |
| A Scaleable Synthesis of Dutasteride: A Selective 5α-Reductase Inhibitor Komati Satyanarayana, Katkam Srinivas, Vurimidi Himabindu, and Ghanta Mahesh Reddy 842-845  |
| Full: PDF (105 K) |
| Characterization of the Polymorphic Behavior of an Organic Compound Using a Dynamic Thermal and X-ray Powder Diffraction Technique David Albers, Michelle Galgoci, Dan King, Daniel Miller, Robert Newman, Linda Peerey, Eva Tai, and Richard Wolf 846-860  |
| Full: PDF (3810 K) |
| A Novel, Safe, and Robust Nitration Process for the Synthesis of 4-(4-Methoxy-3-nitrophenyl)morpholine Pingsheng Zhang, Ashish Shankar, Thomas P. Cleary, Miall Cedilote, Dobbert Locklear, and Michael E. Pierce 861-864  |
| Full: PDF (86 K) |
| Vanishing Microwave Effects: Influence of Heterogeneity Mark H. C. L. Dressen, Bastiaan H. P. van de Kruijs, Jan Meuldijk, Jef A. J. M. Vekemans, and Lumbertus A. Hulshof 865-869  |
| Full: PDF (741 K) |
| Mobile Tool for HPLC Reaction Monitoring Wes A. Schafer, Steve Hobbs, Jason Rehm, David A. Rakestraw, Charles Orella, Mark McLaughlin, Zhihong Ge, and Christopher J. Welch 870-876  |
| Full: PDF (1112 K) |
| Kinetics for Scale-Up of a One-Pot Pathway to 5-(3-Fluorophenyl)-2,4-dihydro-2,4-dimethyl-3H-1,2,4-triazole-3-thione Using a Hybrid Model of Parallel and Consecutive Reactions David H. Louks and Sandra K. Stolz-Dunn 877-884  |
| Full: PDF (660 K) |
| An Alternate Route to 2-Amino-3-nitro-5-bromo-4-picoline: Regioselective Pyridine Synthesis via 2-Nitramino-picoline Intermediate Apurba Bhattacharya, Vikram C. Purohit, Prashant Deshpande, Annie Pullockaran, John A. Grosso, John D. DiMarco, and Jack Z. Gougoutas 885-888  |
| Full: PDF (198 K) |
| Effect of Solvent on Stereoselectivity in Pd/C (Type 39K)-Catalyzed Hydrogenation of Methyl 3-Oxo-4-aza-5-androstene-17-carboxylate, A Key Intermediate for Finasteride and Dutasteride Srihari Babu Karrothu, Naveenkumar Kolla, Amarnath Reddy Lekkala, China Malakondaiah Golla, Ramasamy Vijaya Anand, Venkateswarlu Gandu, Apurba Bhattacharya, Pratap Reddy Padi, and Rakeshwar Bandichhor 889-891  |
| Full: PDF (82 K) |
| A High-Throughput Process for Valsartan Ulrich Beutler, Matthias Boehm, Peter C. Fuenfschilling, Thomas Heinz, Jean-Paul Mutz, Ulrich Onken, Martin Mueller, and Werner Zaugg 892-898  |
| Full: PDF (133 K) |
| A Scaleable Synthesis of Methyl 3-Amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate Eric E. Boros, Svetlana A. Burova, Greg A. Erickson, Brian A. Johns, Cecilia S. Koble, Noriyuki Kurose, Matthew J. Sharp, Elie A. Tabet, James B. Thompson, and Matthew A. Toczko 899-902  |
| Full: PDF (96 K) |
| A Chemoenzymatic Synthesis of an Androgen Receptor Antagonist Rajappa Vaidyanathan, Lynsey Hesmondhalgh, and Shanghui Hu 903-906  |
| Full: PDF (92 K) |
| Practical Alternative Synthesis of 1-(8-Fluoro-naphthalen-1-yl)piperazine Zhijian Zhu, Norm L. Colbry, Mark Lovdahl, Kenneth E. Mennen, Alison Acciacca, Vladimir G. Beylin, Jerry D. Clark, and Daniel T. Belmont 907-909  |
| Full: PDF (82 K) |
| An Improved Synthesis of Rimonabant: Anti-Obesity Drug Vijay Kumar Kotagiri, Sashikanth Suthrapu, Jambula Mukunda Reddy, Chitneni Prasad Rao, Vijaybhaskar Bollugoddu, Apurba Bhattacharya, and Rakeshwar Bandichhor 910-912  |
| Full: PDF (82 K) |
TECHNICAL NOTES
| Green Chemical Synthesis of 2-Benzenesulfonyl-pyridine and Related Derivatives William G. Trankle and Michael E. Kopach 913-917  |
| Full: PDF (137 K) |
| Reduction of Ethyl Benzoylacetate and Selective Protection of 2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol: A New and Facile Synthesis of Tolterodine Kathlia A. De Castro, Jungnam Ko, Daejong Park, Sungdae Park, and Hakjune Rhee 918-921  |
| Full: PDF (86 K) |
| New Synthetic Approach to Memantine Hydrochloride starting from 1,3-Dimethyl-adamantane Mukesh K. Madhra, Mukesh Sharma, and C. H. Khanduri 922-923  |
| Full: PDF (62 K) |
BOOK REVIEWS
| Intellectual Property Management: A Guide for Scientists, Engineers, Financiers, and Managers. By Claas Junghans, Adam Levy, Rolf Sander, and Tobias Boeckh. Wiley-VCH Verlag GmbH: Weinheim. 2006. 170 + xviii pp. Euro 49.90. ISBN 3-527-31286-2. 924-924 |
| Full: PDF (47 K) |
| March’s Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 6th ed. By Michael B. Smith and Jerry March. Wiley Interscience: New York. 2007. 2357 + xx pp. £58.95 (hardback). ISBN 13 978-0-471-72091-1, ISBN 10 0-471-72091-7. 924-924 |
| Full: PDF (47 K) |
| Common Fragrance and Flavor Materials: Preparation, Properties and Uses, 5th ed. By Horst Surburg and Johannes Panten. Wiley-VCH Verlag GmbH: Weinheim. 2006. 318 + xii pp. Euro 139.00. ISBN 3-527-31315-X. 924-924 |
| Full: PDF (47 K) |
| Organic Synthesis – State of the Art 2003–2005. By Douglass F. Taber. Wiley-Interscience: New York. 2006. 216 pp. $99.95. ISBN 0-470-05331-3. 924-925 |
| Full: PDF (46 K) |
| The Art of Drug Synthesis. By Douglas S. Johnson and Jie Jack Li. Wiley-Interscience: New York. 2007. 276 pp. £50.50, $89.95. ISBN 978-0-471-75215-8. 925-925 |
| Full: PDF (46 K) |
| Industrial Biotransformations, 2nd Completely Revised and Extended Edition. A. Liese, K. Seelbach, and C. Wandrey, Eds. Wiley-VCH: Weinheim. 2006. 556 + xiv pp. £149.00. ISBN 3-527-31001-0. 925-926 |
| Full: PDF (46 K) |
| Enantioselective Organocatalysis: Reactions and Experimental Procedures. Edited by Peter I. Dalko. Wiley-VCH: Weinheim. 2007. 536 + xxiii pp. $190.00. ISBN 978-3-527-31522-2. 926-926 |
| Full: PDF (46 K) |